SPRAVATO® (esketamine) is an FDA-approved prescription nasal spray for adults with treatment-resistant depression and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior.
Unlike traditional antidepressants that can take weeks to work, SPRAVATO® works differently and may provide faster relief. Derived from ketamine, it targets NMDA receptors in the brain, helping to restore connections between brain cells that affect mood and thought patterns.
SPRAVATO® is always used in conjunction with an oral antidepressant and must be administered at a certified healthcare setting under medical supervision.
Unlike many antidepressants that require several weeks to show results, SPRAVATO® has demonstrated noticeable symptom improvement in as little as 24 hours in clinical studies.
SPRAVATO® works through a different mechanism than traditional antidepressants. While most antidepressants affect serotonin, norepinephrine, or dopamine, SPRAVATO® acts on the glutamate system in your brain.
By modulating glutamate activity, SPRAVATO® helps restore neural connections and promotes neuroplasticity, your brain’s ability to adapt and form new pathways. This can lead to rapid improvements in depressive symptoms.
SPRAVATO® is FDA-approved for adults with treatment-resistant depression, meaning you’ve tried at least two different antidepressant treatments in your current depressive episode without adequate relief or couldn’t tolerate them.
SPRAVATO® is also approved for adults with major depressive disorder who are experiencing acute suicidal thoughts or behaviors. In these cases, SPRAVATO® is used alongside oral antidepressants to provide rapid intervention.
Your treatment at HOPE Therapeutics begins with a thorough psychiatric evaluation to determine if SPRAVATO® is appropriate for you. We'll review your depression history, previous treatments, current medications, and overall health. Medical screening ensures SPRAVATO® is safe for you.
As a certified SPRAVATO® treatment center, we’re authorized through the SPRAVATO® REMS (Risk Evaluation and Mitigation Strategy) program to administer this medication.
During each treatment session, you'll self-administer SPRAVATO® nasal spray under the direct supervision of our healthcare provider. The administration takes just a few minutes.
What happens during a session:
✅ Check-in and health assessment
✅ Blood pressure monitoring
✅ Self-administration of SPRAVATO® nasal spray
✅ Supervised observation for 2 hours post-treatment
✅ Monitoring for side effects and vital signs
✅ Assessment before discharge
After the initial treatment phase, treatment frequency is reduced based on your response and needs. Your provider will work with you to determine the optimal maintenance schedule. We continue to monitor your progress using standardized depression assessments and adjust your treatment plan as needed.
Throughout your SPRAVATO® treatment, you'll continue taking your oral antidepressant as prescribed. We encourage concurrent psychotherapy to maximize benefits and develop coping strategies.
FDA-Approved for Treatment-Resistant Depression
SPRAVATO® is the first and only FDA-approved nasal spray specifically indicated for treatment-resistant depression, backed by rigorous clinical trials and real-world evidence.
Rapid Symptom Improvement
Many patients begin to notice improvements within hours to days, much faster than traditional antidepressants which can take weeks to show effects.
Non-Invasive Administration
Simple nasal spray delivery. No needles, no IV, no injections. You self-administer the medication under medical supervision.
Proven Effectiveness
Clinical studies show significant reductions in depression scores compared to oral antidepressants alone. SPRAVATO® plus oral antidepressant is more effective than oral antidepressant alone.
Medical Supervision
Every dose is administered in a certified healthcare setting with trained professionals monitoring you throughout the 2-hour observation period.
Treatment for Resistant Depression
Designed specifically for people who haven’t responded to other antidepressants, SPRAVATO® offers new options when other treatments have been exhausted.
Addresses Suicidal Ideation
For patients with acute suicidal thoughts or behaviors, SPRAVATO® can provide rapid intervention alongside standard care.
Complementary to Existing Treatment
Used in combination with your oral antidepressant, allowing you to maintain your current treatment while adding this therapy.
SPRAVATO® has been extensively studied in clinical trials involving thousands of patients with treatment-resistant depression and major depressive disorder.
The most common side effects of SPRAVATO® include:
Most side effects occur shortly after administration and resolve within 1.5 to 2 hours. This is why the 2-hour observation period is required.
Sedation and Dissociation: You may feel sleepy, disconnected from reality, or unable to think clearly. These effects are common but temporary. You’ll be monitored throughout and cannot leave until we determine it’s safe.
Increased Blood Pressure: SPRAVATO® may cause temporary increases in blood pressure. We monitor your blood pressure before, during, and after treatment. Patients with uncontrolled high blood pressure or cardiovascular conditions may not be candidates.
Abuse and Misuse: SPRAVATO® contains esketamine, which can be abused or lead to dependence. This is why it must be administered in a certified healthcare setting under medical supervision. We cannot provide take-home medication.
Do not take SPRAVATO® if you:
Tell your healthcare provider if you:
SPRAVATO® is available only through a restricted program called SPRAVATO® REMS because of the risks of:
As a certified SPRAVATO® treatment center, we:
We are an officially certified SPRAVATO® treatment center enrolled in the REMS program, with healthcare providers specially trained in SPRAVATO® administration and monitoring.
SPRAVATO® is part of our approach to treating depression, which includes medication management and psychotherapy.
We customize your SPRAVATO® treatment schedule based on your individual response, working closely with you to optimize outcomes.
We work with major insurance plans and will verify your coverage, handle prior authorizations, and help you understand your benefits and out-of-pocket costs.
We use validated depression assessment tools to track your progress and provide continuous support throughout your treatment.
Most major insurance plans, including Medicare, cover SPRAVATO® for FDA-approved indications when medical necessity criteria are met. Coverage typically requires:
Our team will verify your insurance benefits, obtain prior authorization, and work with your insurance company to maximize coverage.
Janssen CarePath Savings Program: Eligible commercially insured patients may pay as little as $10 per treatment session. Financial assistance is available for those who qualify.
Financial Counseling: We provide transparent cost information and work with you to explore all financial assistance options, payment plans, and resources.
Explore the inspiring journeys of individuals who have transformed their lives through the clinical use of SPRAVATO®. From overcoming obstacles to reaching significant milestones, these individuals share how SPRAVATO® treatment has been instrumental in reshaping their habits and creating lasting change. Discover real-life stories of success, motivation, and the powerful impact of building sustainable habits for a better life.
Over 3,000+ residents have used SPRAVATO® to elevate their lives.
The duration of treatment varies by individual. Some patients may need treatment for several months, others longer. Your provider will work with you to determine the optimal duration and maintenance schedule based on your response.
If you’ve tried multiple antidepressants without success, SPRAVATO® may be the breakthrough treatment you’ve been searching for. Our certified team is here to guide you through every step of the process.
Our compassionate providers will determine if SPRAVATO® is right for you, explain the treatment process, verify insurance coverage, and answer all your questions.
Download our comprehensive PDF guides to learn about SPRAVATO®, its benefits, uses, and other important safety information.
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Effective Date: Jan 1st, 2026
1. Program Description: This messaging program sends appointment confirmation and reminder messages to customers who have booked an appointment with Hope Therapeutics through our website at https://hopetherapeutics.com/, or via our scheduling forms, and have explicitly opted in to receive SMS notifications. Opt-in is collected via web forms with a dedicated checkbox for SMS consent. Messages include scheduling confirmations, appointment reminders, rescheduling updates, and customer support communications.
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Effective Date: Jan 1st, 2026
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